COMPOSITION PHARMACEUTIQUE CONTENANT SC(FV)2

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专利权人:

CHUGAI SEIYAKU KABUSHIKI KAISHA

发明人:

IGAWA, TOMOYUKI

申请号：

CA2611726

公开号：

CA2611726C

申请日:

2006.06.09

申请国别(地区):

CA

年份:

2017

代理人:

摘要：

The present inventor discovered stabilizing agents/stabilizing conditions forsuppressingisomerization reactions of sc(Fv)2. It was also discovered that the above-mentionedisomerization reactions can be suppressed through use of freeze-driedformulations. Asdisclosed herein, by applying the discovered stabilizing agents/stabilizingconditions or thefreeze-dried formulation, the isomerization reaction of an sc(Fv)2-typemolecule from thebivalent scFv type to the single chain diabody type, and/or the isomerizationreaction from asingle chain diabody type to a bivalent scFv type can be suppressed in bothdirections or onedirection.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/