Provided herein are antibodies and antigen-binding fragments thereof with low or no immunogenicity in humans and optionally with desirable manufacturing properties. Also provided are compositions comprising such antibodies or antigen-binding fragments, methods of using such antibodies, and methods for making such antibodies.本發明提供在人體中具有低免疫原性或無免疫原性且視情況具有所需製造特性之抗體及其抗原結合片段。亦提供包含此類抗體或抗原結合片段之組合物、使用此類抗體之方法及製造此類抗體之方法。