What is closed in system of the present invention has the anti-DR5 antibody of improved characteristics, the composition comprising the antibody such as this, the method for manufacturing with what the antibody such as this and component and its therapeutical uses, is in detail the purposes for the treatment of cancer.本發明係關於具有改良特性之抗-DR5抗體、包含該等抗體之組合物、用於製造該等抗體之方法與構件及其治療用途,詳言之為治療癌症之用途。