The present invention relates to an antibody, recombinant or synthetic antigen-binding fragments thereof able to recognise and bind an epitope comprised in the spacer domain of ADAMTS-5, nucleic acid and expression vector encoding the same, method of production and uses thereof.本發明係關於一種能夠識別且結合ADAMTS-5間隔子結構域中所包含之抗原決定基的抗體、其重組或合成抗原結合片段、編碼其之核酸及表現載體、製造方法及其用途。