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NOVEL PHENYLPYRROLE DERIVATIVE
专利权人:
Yukari ONISHI;Takeshi HONDA;Akihiro FURUKAWA;Yumi MATSUI;Kenjiro UEDA;Tetsuyoshi MATSUFUJI;Takehiro FUKUZAKI;Hideki KOBAYASHI;Masahiro KONISHI
发明人:
Akihiro FURUKAWA,Takehiro FUKUZAKI,Yukari ONISHI,Hideki KOBAYASHI,Takeshi HONDA,Yumi MATSUI,Masahiro KONISHI,Kenjiro UEDA,Tetsuyoshi MATSUFUJI
申请号:
US13198819
公开号:
US20120022075A1
申请日:
2011.08.05
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present invention relates to a compound or a pharmacologically acceptable salt thereof having superior glucokinase activating activity, and is a compound represented by general formula (I), or pharmacologically acceptable salt thereof:[wherein,A represents, for example, an oxygen atom or sulfur atom, R1 represents, for example, a C1-C6 alkyl group, a C1-C6 alkoxy group or a C1-C6 halogenated alkyl group, A and R1 together with the carbon atom bonded thereto form a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group α, R2 represents a phenyl group that may be substituted with 1 to 5 group(s) independently selected from Substituent Group α or a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group α, R3 represents a hydroxy group or a C1-C6 alkoxy group, and Substituent Group α consists of, for example, a halogen atom, a C1-C6 alkyl group, a C1-C6 alkyl group substituted with 1 or 2 hydroxy group(s), a C1-C6 alkylsulfonyl group, and a group represented by the formula —V—NR5R6 (wherein, V represents a carbonyl group or a sulfonyl group, and R5 and R6 may be the same or different and respectively represent a hydrogen atom or a C1-C6 alkyl group, or R5 and R6 together with the nitrogen atom bonded thereto form a 4- to 6-membered saturated heterocycle that may be substituted with 1 or 2 group(s) independently selected from a C1-C6 alkyl group and a hydroxy group, and the 4- to 6-membered saturated heterocycle may further contain one oxygen atom or nitrogen atom)].
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