ОНИСИЮ Даниела Кармен (FR),ДАССЕ Жан-Луи Анри (FR),БАРБАРА Рональд (FR),КОЧУБЕЙ Валерий (RU),КОВАЛЬСКИЙ Дмитрий (RU),РОДИН Олег Геннадьевич (RU),ЖОФФРУА Отто (US),РЗЕПИЛА Анна (NL)
申请号：
RU2013122834/04
公开号：
RU2013122834A
申请日:
2011.10.18
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. The compound of Formula (II): or a pharmaceutically acceptable salt thereof, wherein each R independently is —H, —hydrocarbyl, aryl, aralkyl, heteroaryl, heterocyclyl, —C (O) O (alkyl), —OC (O) (alkyl), —C (O) NH, —C (O) NH (alkyl), —C (O) N (alkyl) (alkyl), —NHC (O) (alkyl), N (alkyl) C (O ) (alkyl) or -SONH； each R independently represents -H, -OH, -NH, -NH (alkyl), -N (alkyl) (alkyl), hydrocarbyl, -O-alkyl, -O-alkenyl, aryl, -O-aryl, aralkyl, -O-aralkyl, heteroaryl, -O-heteroaryl, heterocyclyl, -O-heterocyclyl, halogen, -OCF, -C (O) O (alkyl), -OC (O) (alkyl), -C (O) NH, -C (O) NH (alkyl), -C (O) N (alkyl) (alkyl), NHC (O) (C-C-alkyl), N (alk k) C (O) (alkyl), -OC (O) O (alkyl), -OC (O) NH, -OC (O) NH (alkyl), -OC (O) N (alkyl) (alkyl), -CHNH, -CHN (alkyl) or -SONH； each of Q, Q and Q independently represents CR or N； X represents CHR, S, O or NR； and each m independently represents an integer from 0 to 3.2. A compound or pharmaceutically acceptable salt according to claim 1, characterized in that R is H and R is OH； 3. A compound or pharmaceutically acceptable salt according to claim 2, characterized in that each m is 1.4. A compound according to claim 1, characterized in that the compound is: or a pharmaceutically acceptable salt of any of the above compounds. A composition comprising an effective amount of a compound or pharmaceutically acceptable salt of a compound according to claim 1 and a pharmaceutically acceptable excipient or carrier. A composition according to claim 5, characterized in that said composition is formulated for oral administration. A composition according to claim 5, characterized in that said composition is in the form of a tablet or capsule. The composition according to claim 5, characterized in that the compound or its salt is present in an amount of from about 1 mg to1. Соединение Формулы (II):или его фармацевтически приемлемая соль, гдекаждый Rнезависимо представляет собой -Н, -гидрокарбил, арил, -аралкил, -гетероарил, -гетероцикл
