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DERIVADOS DE PIRROLIDINONA HETEROAROMATICAS FUSIONADAS, COMPOSICIONES FARMACEUTICAS QUE LAS CONTIENEN Y USO DE LAS MISMAS PARA TRATAR AFECCIONES DEL SISTEMA INMUNE Y LA INFLAMACION
专利权人:
TAKEDA PHARMACEUTICAL COMPANY LIMITED
发明人:
ARIKAWA YASUYOSHI,FEHER VICTORIA,LAM BETTY,NIE ZHE,DONG QING,JONES BENJAMIN,SMITH CHRISTOPHER,TAKAHASHI MASASHI
申请号:
ARP100104923
公开号:
AR081797A1
申请日:
2010.12.22
申请国别(地区):
AR
年份:
2012
代理人:
摘要:
Claim 1: a compound of formula (1) or its Salt acceptable for pharmaceutical use: G is selected, where N and C (R5), L1 and L2 are selected each one of them independently of NH and link R1 and R2 are each independently selected from Hydrogen, alkyl, Halo C1 - 3 - 3, and haloalquilo C1, R1 and R2, together with the Atom to which they are United.Form a cycloalkyl C3 - 6 R3 is selected from alkyl C2 - 6, - 8 heterocicloalquilo cycloalkyl C3, C2 and C1 - heteroaryl - 5, 9, each optionally substituted with one to Five Selected regardless of Halo substituents, oxo -, NO2 -, alkyl - 6 ns, C1, C2 alquenilo - 6 alquinilo C2 - 6, halo Rent haloalquenilo C1 - C2 - 6, 6, 6 haloalquinilo C2, R6,R4 and R7 select of cycloalkyl heterociclilo C2 - C3 - 8, 5, aryl and heteroaryl C1 - C6 14 9, each optionally substituted with one to Five Selected regardless of Halo substituents, oxo alkyl, - CN, - 6 alquenilo C1, C2 alquinilo - 6 - 6, C2, C1 - haloalquilo 6, haloalquenilo C2, 6 Loalquinilo C2 - 6, R6 and R7 R5 is selected from Hydrogen, alkyl, Halo, Oh, CN, c1-4,Heterociclilo heteroaryl C1 - C2 - 5, 5, and R6, where the rest heterociclilo has 3 to 6 Atoms of the ring and the rest heteroaryl has 5 or 6 Atoms of the ring, and the remains heterociclilo and heteroaryl are each optionally substituted with one to four substituents selected in Dependently of Halo, NO2, - CN, c1-4 alkyl, alquenilo C2 - 4 - 4 haloalquilo alquinilo C2, C1 - 4Haloalquenilo C2 - 4, haloalquinilo c2-4, R6 and R7 R6 each is selected regardless of or7 - N (R7, R8), nr7c (R8) -, - C (o) R7, - C (o) or7, - C (o) n (R7 R8, - c) (o) n (R7) 0R8, - C (o) n (R7) s (or 2r8), - N (R7) s (or S) 2r8, nr7 and (OR) - S (o) 2N (R7 R8 R7 and R8) each is selected independently Hydrogen or of alqui The C1 - C2 - alquenilo 6, 6, 6 alquinilo cycloalkyl C2, C3 - 6 - (CH2) aryl C6 - 14 m -, M -, - (CH2)Heterociclilo C2 - 5 - (CH2) m, and heteroaryl C1 - 9 - (CH2) M - each optionally substituted with one to Five Selected regardless of Ha
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