ALEXANDER, RIKKI PETER,AUJLA, PAVANDEEP,BATCHELOR, MARK JAMES,BROOKINGS, DANIEL CHRISTOPHER,BUCKLEY, GEORGE MARTIN,CREPY, KAREN VIVIANE LUCILE,KULISA, CLAIRE LOUISE,TURNER, JAMES PETRIE
申请号：
ES06726894
公开号：
ES2373680T3
申请日:
2006.04.25
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
The use, for the manufacture of a medicament for the treatment and / or prevention of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nocirreceptive and ophthalmic conditions, of a compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof: in which -X- represents a group of formula (a), (b), (c), (d), (e), (f), (g) or (h): R 1 and R 2 independently represent hydrogen； or C1-6 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl (C1-6) alkyl, aryl, aryl (C1-6) alkyl, C3-7 heterocycloalkyl, C3-7 alkylcycloalkyl of (C1-6), heteroaryl or heteroaryl (C1-6) alkyl, any of whose groups may be optionally substituted with one or more substituents； or R 1 and R 2, when both are attached to the same carbon atom, represent, when taken together with the carbon atom to which both are attached, C3-7 cycloalkyl or C3-7 heterocycloalkyl, any of whose groups it may be optionally substituted with one or more substituents； or R 1 and R 2, when attached to adjacent carbon atoms, represent, when taken together with the carbon atoms to which they are attached, C5-7 cycloalkyl, phenyl or heteroaryl, any of whose groups may optionally be benzo condensate and / or substituted with one or more substituents； R 3 and R 4 independently represent hydrogen； or C1-6 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl (C1-6) alkyl, aryl, aryl (C1-6) alkyl, (C2-6) aryl-alkenyl, aryl- (C2-6) alkynyl, (C1-6) biaryl-alkyl, C3-7 heterocycloalkyl, C3-7 heterocycloalkyl (C1-6) alkyl, C3-7 carbonyl heterocycloalkyl, heteroaryl, heteroaryl-alkyl (C1-6), heteroaryl-aryl-alkyl of (C1-6) or aryl-heteroaryl-alkyl of (C1-6), any of whose groups may be optionally substituted with one or more substituents； or R 3 and R 4, when both are attached to the same carbon atom, represent, when taken together with the carbon atom to which both are attached, C3-7 cycloalkyl or C3-7 heterocycloalkyl, any of whose groups it may be optionally substituted with one or more substituents； or R 3 an
