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Pyrrolopyrimidinylamino-benzothiazolones substituted as MKNK kinase inhibitors
专利权人:
Bayer Pharma Aktiengesellschaft
发明人:
KLAR, Ulrich,WORTMANN, Lars,KETTSCHAU, Georg,PUEHLER, Florian,LIENAU, Philip,PETERSEN, Kirstin,HÄGEBARTH, Andrea,SÜLZLE, Detlev,RICHTER, Anja
申请号:
ES13766493
公开号:
ES2612378T3
申请日:
2013.09.18
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound of general formula I: ** Formula ** in which R1a represents a hydrogen atom or a halogen atom or a hydroxy-, cyano-, C1-C6-alkyl, C1-C6-haloalkyl, C1- alkoxy group C6-, halo-C1-C6-alkoxy, C3-C6-cycloalkyloxy, (3- to 10-membered heterocycloalkyl) -O-, - NR5aR5b, -SCF3 or -SF5; R1b represents a hydrogen atom or a halogen atom or a group hydroxy-, cyano-, C1-C6-alkyl, halo C1-C6-alkyl, C1-C6-alkoxy, halo-C1-C6-alkoxy, C3-cycloalkyloxy C6-, (3-10 membered heterocycloalkyl) -O-, - NR5aR5b, -SCF3 or -SF5; R1c represents a hydrogen atom or a halogen atom or a group hydroxy-, cyano-, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C3-C6-cycloalkyloxy -, (3-10 membered heterocycloalkyl) -O-, - NR5aR5b, -SCF3 or -SF5; Y represents N or CR2a; Z represents N or CR2b; with the proviso that not more than one of Y and Z represents N; R2a represents a hydrogen atom or a halogen atom or a group selected from: C1-C6-alkyl, C2-C6-alkenyl, C3-C6-alkynyl, C3-C6-cycloalkyl, 3- to 10-membered heterocycloalkyl-, heterocycloalkenyl - from 4 to 10 members, aryl-, heteroaryl-, halo-C1-C3-alkyl-, cyano-, - (CH2) qX- (CH2) p-R3; wherein said C1-C6-alkyl, C3-C6-cycloalkyl-, 3-10 membered heterocycloalkyl-, 4-10 membered heterocycloalkenyl-, aryl- or heteroaryl- are optionally substituted, identically or differently, with 1 , 2, 3, 4 or 5 R4 groups; R2b represents a hydrogen atom or a halogen atom or a group selected from: C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C6-cycloalkyl, 3- to 10-membered heterocycloalkyl-, heterocycloalkenyl - from 4 to 10 members, aryl-, heteroaryl-, halo-C1-C3-alkyl-, cyano-, - (CH2) qX- (CH2) p-R3; wherein said C1-C6-alkyl, C3-C6-cycloalkyl-, 3-10 membered heterocycloalkyl-, 4-10 membered heterocycloalkenyl-, aryl- or heteroaryl- are optionally substituted, identically or differently, with 1 , 2, 3, 4 or 5 R4 groups; X represents a single bond or a bivalent group selected from: -O-, -S-, -S (>; = O) -, -S (>; = O) 2-, -S (>; = O) - (NR3a) -, - (NR3a)
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