PETIT, ROBERT,WALLECHA, ANU,KHLEIF, SAMIR,CHEN, ZHISONG,BERZOFSKY, JAY A.
申请号：
SG11201700090R
公开号：
SG11201700090RA
申请日:
2015.07.17
申请国别(地区):
SG
年份:
2017
代理人:
摘要：
The present invention is directed to compositions comprising an immune checkpoint inhibitor or a T cell stimulator or a combination thereof, and a live attenuated recombinant Listeria strain comprising a fusion polypeptide comprising a truncated Listeriolysin O protein, a truncated ActA protein, or a PEST amino acid sequence fused to a tumor-associated antigen. The invention is further directed to methods of treating, protecting against, and inducing an immune response against a tumor or a cancer, comprising the step of administering the same.
