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TREATMENT OF BACTERIAL INFECTIOUS DISEASES
专利权人:
ЮНИВЕРСИТИ ОФ ЦЮРИХ;ЕТХ ЦЮРИХ;ЮНИВЕРСИТИ ОФ ЦЮРИХ
发明人:
БЁТТГЕР Эрик,ФАЗЕЛЛА Андреа
申请号:
RU2013116742
公开号:
RU2013116742A
申请日:
2011.09.12
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. Apramycin of formula (I) is a derivative of apramycin or its acid addition salt for use in the treatment of bacterial infectious diseases in humans. Apramycin, an apramycin derivative or an acid addition salt thereof according to claim 1, wherein the acid addition salt is a pharmaceutically acceptable acid addition salt for use in the treatment of bacterial infectious diseases in humans. Apramycin of formula (I) or a pharmaceutically acceptable acid addition salt thereof according to claim 1 for use in the treatment of bacterial infectious diseases in humans. The apramycin derivative of formula (I) according to claim 1, in which one or more amino groups are alkylated, cycloalkylated, alkenylated and / or acylated, or replaced by a hydroxy group, and / or one or more hydroxy groups are alkylated, alkenylated, acylated and / or replaced by an amino group , and / or two adjacent hydroxy groups are cyclized to form acetal or carbonate, and / or the adjacent hydroxy group and amino group are cyclized to form amino acetal or carbamate, and / or the 7'-NHCH group is replaced by NH, alkylated, cycloal a kylated, alkenylated and / or acylated amino group, a hydroxy group, an alkylated, cycloalkylated, alkenylated or acetylated hydroxy group and / or a 3'-carbon atom is substituted with an amino group NH or an alkylated, cycloalkylated, alkenylated and / or acylated amino group, or or an acylated hydroxy group, and / or a 5- and / or 6-hydroxy group is glycosylated with a monosaccharide, and / or a ring I or a ring III �1. Апрамицин формулы (I)производное апрамицина или его кислотно-аддитивная соль для применения при лечении бактериальных инфекционных заболеваний у человека.2. Апрамицин, производное апрамицина или его кислотно-аддитивная соль по п.1, где кислотно-аддитивная соль представляет собой фармацевтически приемлемую кислотно-аддитивную соль, для применения при лечении бактериальных инфекционных заболеваний у человека.3. Апрамицин формулы (I) или его фармацевтически
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