AQUEOUS LIQUID CONTAINING GATIFLOXACIN, METHOD FOR PRODUCTION THEREOF, AND METHOD FOR PREVENTION OF PRODUCTION OF PRECIPITATES DURING STORAGE OF THE AQUEOUS LIQUID AT LOW TEMPERATURE OR UPON FREEZING/THAWING OF THE AQUEOUS LIQUID
There is provided an aqueous liquid preparation comprising 0.65 to 2 w/v% of Gatifloxacin or a pharmacologically acceptable salt thereof or a hydrate thereof as free Gatifloxacin, and at least 0.5 w/v% of at least one of the ingredient selected from the group consisting of phosphoric acid, malonic acid, nicotinamide and a salt thereof, wherein a pH thereof is 5.8 to 6.9. In the aqueous liquid preparation, the solubility of Gatifloxacin is increased and the formation of a precipitate during storage at a lower temperature and at the time of freezing and thawing of the aqueous liquid preparation is suppressed by incorporating at least one of the ingredient selected from the group consisting of nicotinamide, caffeine, methylglucamine and Methyl parahydroxybenzoate into the aqueous liquid preparation.
