Exposure to cancer treatments, including effective treatment of a formula compound (1),It's either a medically acceptable salt or an ester of someone in need In addition, the methods to inhibit the growth and proliferation of cancer cells in vitro are also disclosed, including linking the cells with a certain number of effective formula compounds (1) to inhibit the growth or proliferation of cancer cells. In addition, the methods of inhibiting tumor growth are also disclosed, including the correlation between tumor and the number of effective formula (1) compounds for inhibiting tumor growth. Requirement 1: a way to treat cancer patients,It has the characteristics that it includes a formula compound (1) needed for managing a cancer patient, an effective treatment amount,Wherein: R1 is No. 83088r83099,optionally substituted C₁₋₆ alkoxy, optionally substituted C₆₋₁₄ aryl, optionally substituted heteroaryl, optionally substituted 3 to 10 membered monocyclic or bicyclic cycloalkyl, or optionally substituted 3 to 10 membered bicyclic monocyclic heterocyclyl, as long as: (i) the cycloalkyl and 3- to 4-membered heterocyclyl are saturated； (ii) hydrogen atoms in the same carbon atom of said cycloalkyl or heterocyclyl are optionally replaced with an optionally substituted 3 to 6 membered cycloalkyl or heterocyclyl to form a spirocycloalkyl or heterocyclyl spiro；and (iii) hydrogen atoms in the same atom of said cycloalkyl or heterocyclyl are optionally replaced with O to form an oxo substituent； R² is optionally substituted phenyl, -O- (optionally substituted C₁₋₆ alkyl) -phenyl, or 5-6 membered heteroaryl, provided that when R² is 4-pyridyl, the 4-pyridyl lacks a substituent carbonyl in the second position； R⁴ and R⁵ are: (a) independently selected from the group consisting of H, C₁₋₆ alkyl,C₁₋₆ hydroxyalkyl,C₃₋₈ cycloalkyl,and - (C₁₋₆ alkyl) N (C₁₋₆ alkyl) (C₁₋₆ alkyl)；(b) The hydrogen atom in the same isomerized carbon atom is replaced by epoxy or isomerized isomerization
