Osaka University;Medical & Biological Laboratories Co., Ltd.;Department of Medical Sciences
发明人:
申请号：
EP14859656.2
公开号：
EP3070167A4
申请日:
2014.11.06
申请国别(地区):
EP
年份:
2017
代理人:
摘要：
From PBMCs of patients infected with H1N1pdm, three human monoclonal antibodies have been obtained which are capable of binding to an epitope present at residues 40 to 58 in an HA2 region of a hemagglutinin protein derived from H1N1pdm. Further, these antibodies have been found to also have a neutralization activity against subtype H1 and subtype H5 of group 1 influenza A viruses. On the other hand, the three antibodies have also been found to exhibit neither a binding ability nor a neutralization activity against subtype H2 which belongs to the group 1, but in the HA2 region derived from H1N1pdm of which the amino acid at residue 45 is substituted with phenylalanine and the amino acid at residue 47 is substituted with glycine.
