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NOVEL AMIDE DERIVATIVE AND USE THEREOF AS MEDICINAL AGENT
专利权人:
MITSUBISI TANABE FARMA KORPOREJSHN
发明人:
ISIBUTI Sejgo (JP),ИСИБУТИ Сейго (JP),KhIKAVA Khidemasa (JP),ХИКАВА Хидемаса (JP),TARAO Akiko (JP),ТАРАО Акико (JP),EhNDOKh Dzun-iti (JP),ЭНДОХ Дзун-ити (JP),ADATI Kunitomo (JP),АДАТИ Кунитомо (JP),MA,ISIBUTI SEJGO,ИСИБУТИ Сейго,KHIKAVA KHIDEMASA,ХИКАВА Хидемаса,TARAO AKIKO,ТАРАО Акико,EHNDOKH DZUN-ITI,ЭНДОХ Дзун-ити,ADATI KUNITOMO,АДАТИ Кунитомо,MAEDA KAZUKHIRO,МАЕДА Казухиро,TASIRO KAORU,ТАСИРО К
申请号:
RU2011121362/04
公开号:
RU0002487124C2
申请日:
2009.10.27
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
FIELD: chemistry.SUBSTANCE: invention relates to an amide derivative of formula (I), where A is benzene or pyridine, where the benzene or pyridine optionally contain 1 or 2 or 3 identical or different substitutes selected from an alkyl containing 1-6 carbon atoms, a cycloalkyl containing 3-6 carbon atoms, an alkoxy containing 1-6 carbon atoms, a halogen atom, nitro, cyano, alkylsulphonyl containing1-6 carbon atoms, amino, cyclic amine selected from 1,1-di-oxoisothiazolidinyl, 2-oxooxazolidinyl, oxopyrrolidinyl, 1,1-dioxothiazinyl and 2-oxoimidazolidinyl optionally having a substitute selected from an alkyl containing 1-6 carbon atoms and an alkylcarbonyl containing a total of 2-7 carbon atoms, acylamino containing a total of 2-7 carbon atoms, and an alkylsulphonyl amino containing 1-6 carbon atoms, wherein the right-side bond is linked to the carbonyl and the left-side bond is linked to the nitrogen atom, R1 and R2 are identical or different and each is a hydrogen, an alkyl containing 1-6 carbon atoms and optionally containing 3 halogen atoms as substitutes, a cycloalkyl containing 3-6 carbon atoms, a phenyl, a halogen atom or a cyano group and R1 and R2 are not a hydrogen atom at the same time, R3 is a hydrogen atom, an alkyl containing 1-6 carbon atoms, an alkenyl containing 2-6 carbon atoms, a cycloalkyl containing 3-6 carbon atoms, or a halogen, R4a, R4b and R4c are each independently a hydrogen atom, an alkyl containing 1-6 carbon atoms, or an oxo, R5a, R5b and R5c are identical or different and each is a hydrogen atom, an alkyl containing 1-6 carbon atoms and optionally containing substitute(s) selected from phenyl, an alkoxy group containing 1-6 carbon atoms, optionally substituted with an alkoxy group containing 1-6 carbon atoms, a phyenylcarbonyloxy group and a hydroxy group, or a phenyl, X is a carbon atom (any of R4a, R4b and R4c can be bonded to a carbon atom, but the carbon atom is not substituted with oxo) or a nitrogen atom (if Y is a single bond, th
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