EKHART, PETER FRANK,VAN DER SAAG, HANS,POSSEMIERS, SAM,VAN DEN ABBEELE, PIETER,VAN DE WIELE, TOM,NEYRINCK, AUDREY MARTINE,DELZENNE, NATHALLE MARIA NELLY,CANI, PATRICE D.
申请号：
CA2733551
公开号：
CA2733551C
申请日:
2009.08.18
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present invention is directed to a particular arabinoxylan("AX") preparation and the finding that this preparation has a beneficialeffect on the organization of the intestinal microbial community in thelumen and in particular at the site of the gut mucosa, where it modulatesthe barrier function of the intestinal surface, primarily by modulating themucosa-associated microbial community towards a relative increase ofhealth beneficial bacteria, such as bifidobacteria and lactobacilli. It isaccordingly a first aspect of the present invention to provide saidarabinoxylanpreparation characterized in comprising isolated water-soluble arabinoxylansand the use thereof to improve functioning (e.g. barrier function)of the intestinal epithelium. Thus, in a further aspect the present inventionprovides compositions, both pharmaceutical and nutritional compositions,comprising said arabinoxylan preparations； in particular pharmaceuticals,medical foods, food supplements or food compositions, such as infantformula products, dairy products, bakery products or pastry products. Thecompositions optionally comprise probiotics such as Bifidobacterium orLactobacillus.
