Pieter Van Den Abbeele;Tom Van De Wiele;Nathalie Maria Nelly Delzenne;Peter Frank Ekhart;Hans Van De Saag;Sam Possemiers;Patrice D. Cani;Audrey Martine Neyrinck
发明人:
Peter Frank Ekhart,Hans Van De Saag,Sam Possemiers,Pieter Van Den Abbeele,Tom Van De Wiele,Audrey Martine Neyrinck,Nathalie Maria Nelly Delzenne,Patrice D. Cani
申请号：
US13059293
公开号：
US20120230955A1
申请日:
2009.08.18
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention is directed to a particular arabinoxylan (“AX”) preparation and the finding that this preparation has a beneficial effect on the organization of the intestinal microbial community in the lumen and in particular at the site of the gut mucosa, where it modulates the barrier function of the intestinal surface, primarily by modulating the mucosa-associated microbial community towards a relative increase of health beneficial bacteria, such as bifidobacteria and lactobacilli. It is accordingly a first aspect of the present invention to provide said arabinoxylan preparation characterized in comprising isolated water-soluble arabinoxylans and the use thereof to improve functioning (e.g. barrier function) of the intestinal epithelium. Thus, in a further aspect the present invention provides compositions, both pharmaceutical and nutritional compositions, comprising said arabinoxylan preparations； in particular pharmaceuticals, medical foods, food supplements or food compositions, such as infant formula products, dairy products, bakery products or pastry products. The compositions optionally comprise probiotics such as Bifidobacterium or Lactobacillus.
