Method for preparation of fluorine-18-labeled flumazenil using diaryliodonium salt precursor

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专利权人:

Bio Imaging Korea Co.; Ltd.

发明人:

Byung Chul Lee,Byung Seok Moon,Ji Sun Kim

申请号：

US14087537

公开号：

US08895727B2

申请日:

2013.11.22

申请国别(地区):

US

年份:

2014

代理人:

摘要：

Disclosed is the synthesis of [18F]flumazenil that is useful in imaging epileptic lesions by PET (positron emission tomography). A method for preparing [18F]flumazenil by reacting a diaryliodonium salt precursor with the positron-emitting radionuclide fluorine-18. [18F]flumazenil can be prepared from the diaryliodonium salt precursor in the presence of kryptofix2.2.2./potassium carbonate(K2.2.2./K2CO3) and TEMPO in dimethylformamide (DMF) at a high yield.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/