PREPARATION METHOD OF FLUMAZENIL LABELED WITH FLUORINE-18 USING DIARYL IODONIUM SALT PRECURSOR

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专利权人:

BIO IMAGING KOREA CO.; LTD.

发明人:

LEE, BYUNG CHUL,MOON, BYUNG SEOK,KIM, JI SUN

申请号：

EP11866152

公开号：

EP2719387A4

申请日:

2011.06.03

申请国别(地区):

EP

年份:

2014

代理人:

摘要：

Disclosed is the synthesis of [18F]flumazenil that is useful in imaging epileptic lesions by PET (positron emission tomography). A method for preparing [18F]flumazenil by reacting a diaryliodonium salt precursor with the positron-emitting radionuclide fluorine-18. [18F]flumazenil can be prepared from the diaryliodonium salt precursor in the presence of kryptofix2.2.2./potassium carbonate(K2.2.2./K2CO3) and TEMPO in dimethylformamide (DMF) at a high yield.

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中国工程科技知识中心

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http://www.ckcest.cn/home/