The present invention relates to a combination therapy comprising an effective amount of an immune checkpoint molecular modulator and an effective amount of an MDM2 inhibitor, where the MDM2 inhibitor is represented by the following formula: , Or a pharmaceutically acceptable salt thereof.本發明關於包含有效量免疫檢查點分子調節劑和有效量MDM2抑制劑的聯合療法,其中MDM2抑制劑由下式表示:,或其藥學上可接受的鹽。