SMITH, LARRY,CASSETTI, MARIA CRISTINA,MCELHINEY, SUSAN P.,PULLEN, JEFFREY K.
申请号：
CA2499837
公开号：
CA2499837C
申请日:
2003.10.02
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The present invention provides immunogenic and pharmaceutical compositions forthe treatment and prevention of human papillomavirus (HPV)-associated cancersand in particular, cervical cancer. In particular, this invention relates tofusion proteins, and the nucleic acids encoding these fusion proteins, used togenerate immune responses against HPV. Specifically, this invention providesfor fusions of HPV E6 and E7 in which the E6 and/or E7 contains one or moremutations. These mutations abrogate the transformation activity of theseoncogenic proteins and, thus, confer safety to the E6/E7 fusions. In addition,these fusions maintain or increase the immunogenic efficacy of E6 and E7. Anygene or protein delivery method can be used to deliver or package theimmunogenic compositions of the present invention.
