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Muscle contraction inhibitor compounds
专利权人:
LIPOTEC; S.A.
发明人:
GARCIA SANZ, NURIA,VAN DEN NEST, WIM,CARRENO SERRAÏMA, CRISTINA,FERRER MONTIEL, ANTONIO,CEBRIAN PUCHE, JUAN,ALMINANA DOMENECH, NURIA,FERNANDEZ BALLESTER, GREGORIO
申请号:
ES10736634
公开号:
ES2527022T3
申请日:
2010.07.23
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
A peptide of the general formula (I) R1-Wn-Xm-AA1-AA2-AA3-AA4-AA5-AA6-Yp-Zs-R2 (I) its stereoisomers, mixtures thereof and / or their cosmetically or pharmaceutically acceptable salts , characterized in that: AA1 is selected from the group consisting of -Asp-, -Glu- and -Pro-; AA2 is -Asp-; AA3 is selected from the group consisting of -Tyr- and -Arg-; AA4 is selected from the group consisting of -Phe- and -Tyr-; AA5 is selected from the group consisting of -Arg- and -Lys-; AA6 is selected from the group consisting of -Leu- and -Met-; W, X, Y and Z are independently selected from each other from the group consisting of the encoded and uncoded amino acids; n, m, p and s are independently selected from each other and have a value between 0 and 1; R1 is selected from the group consisting of H, substituted or unsubstituted non-cyclic aliphatic group, substituted or unsubstituted alicyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl and R5- CO- where R5 is selected from the group consisting of H, substituted or unsubstituted aliphatic group, substituted or unsubstituted alicyclyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, substituted or unsubstituted heterocyclyl and substituted or unsubstituted heteroarylalkyl ; and R2 is selected from the group consisting of -NR3R4, -OR3 and -SR3, where R3 and R4 are independently selected from the group consisting of H, substituted or unsubstituted aliphatic group, substituted or unsubstituted alicyclic, substituted or unsubstituted heterocyclyl , substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted aryl, and substituted or unsubstituted aralkyl.Un péptido de fórmula general (I) R1-Wn-Xm-AA1-AA2-AA3-AA4-AA5-AA6-Yp-Zs-R2 (I) sus estereoisómeros, mezclas de los mismos y/o sus sales cosmética o farmacéuticamente aceptables, caracterizado porque: AA1 se selecciona del gru
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