MODIFIED COMPSTATIN WITH PEPTID BACKBONE AND C-TERMINAL MODIFICATIONS

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专利权人:

The Trustees Of The University Of Pennsylvania

发明人:

LAMBRIS, John D.,QU, Hongchang

申请号：

DK10718379

公开号：

DK2424557T3

申请日:

2010.05.03

申请国别(地区):

DK

年份:

2018

代理人:

摘要：

Compounds comprising peptides capable of binding C3 protein and inhibiting complement activation are disclosed. These compounds display greatly improved complement activation-inhibitory activity as compared with currently available compounds. The compounds comprise compstatin analogs having a constrained backbone at position 8 (glycine) and, optionally, specific substitutions for threonine at position 13.

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中国工程科技知识中心

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