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Modified compstatin with peptide backbone and C-terminal modifications
专利权人:
John D. Lambris;Hongchang Qu
发明人:
John D. Lambris,Hongchang Qu
申请号:
US13318272
公开号:
US08946145B2
申请日:
2010.05.03
申请国别(地区):
US
年份:
2015
代理人:
摘要:
Compounds comprising peptides capable of binding C3 protein and inhibiting complement activation are disclosed. These compounds display greatly improved complement activation-inhibitory activity as compared with currently available compounds. The compounds comprise compstatin analogs having a constrained backbone at position 8 (glycine) and, optionally, specific substitutions for threonine at position 13.
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中国工程科技知识中心
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