MODIFIED COMPSTATIN WITH PEPTIDE BACKBONE AND C-TERMINAL MODIFICATIONS

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专利权人:

发明人:

JOHN D LAMBRIS,HONGCHANG QU

申请号：

IN8692/DELNP/2011

公开号：

IN2011DN08692A

申请日:

2011.11.08

申请国别(地区):

IN

年份:

2013

代理人:

摘要：

Compounds comprising peptides capable of binding C3 protein and inhibiting complement activation are disclosed. These compounds display greatly improved complement activation-inhibitory activity as compared with currently available compounds. The compounds comprise compstatin analogs having a constrained backbone at position 8 (glycine) and, optionally, specific substitutions for threonine at position 13.

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