OLHAVA, Edward,CHESWORTH, Richard,KUNTZ, Kevin,RICHON, Victoria,POLLOCK, Roy,DAIGLE, Scott
申请号：
ES11804836
公开号：
ES2577027T3
申请日:
2011.12.02
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of Formula (IV) or its N-oxide or a pharmaceutically acceptable salt thereof: ** Formula ** wherein A is O or CH2； Q is H, NH2, NHRb, NRbRc, OH, Rb, or ORb, where each of Rb and Rc is independently C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3- cycloalkyl C8, C6-C10 aryl, 4-7 membered heterocycloalkyl, 5-10 membered heteroaryl, or -M1-T1, wherein M1 is a C1-C6 alkyl bond or linker optionally substituted with halo, cyano, hydroxy or C1-C6 alkoxy, and T1 is C3-C8 cycloalkyl, C6-C10 aryl, 4-6 membered heterocycloalkyl, or 5-10 membered heteroaryl, or Rb and Rc, together with the N al atom which are attached, form a 4- to 7-membered heterocycloalkyl having 0 or 1 additional heteroatom to the N atom optionally substituted with C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, halo, hydroxyl, carboxyl, C (O) OH, C (O) O-C1-C6 alkyl, OC (O) -C1-C6 alkyl, cyano, C1-C6 alkoxy, amino, mono-C1-C6-alkyl-amino, di- C1-C6-amino alkyl, C3-C8 cycloalkyl, C6-C10 aryl, 4-6 heterocycloalkyl members, or 5-6 membered heteroaryl, and each of Rb, Rc, and T1 is optionally substituted with one or more substituents selected from C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, halo, hydroxy, carboxyl, cyano, C1-C6 alkoxy, amino, mono-C1-C6-alkyl, di-C1-C6-alkyl, C3-C8 cycloalkyl, C6-C10 aryl, 4-6 membered heterocycloalkyl , and 5-6 membered heteroaryl； X is N or CRx, where Rx is H, halo, hydroxyl, carboxyl, cyano, or RS1, with RS1 amino, C1-C6 alkoxy, C1-C6 alkyl, C2-C6 alkenyl, C2- alkynyl C6, C3-C8 cycloalkyl, C6-C10 aryl, 4-6 membered heterocycloalkyl, or 5-6 membered heteroaryl, and RS1 being optionally substituted with one or more substituents selected from halo, hydroxyl, carboxyl, cyano, alkoxy C1-C6, amino, mono-C1-C6-alkyl, di-C1-C6-alkyl, C3-C8 cycloalkyl, C6-C10 aryl, 4-6 membered heterocycloalkyl, and 5-6 heteroaryl members； Y is H, Rd, SO2Rd, or CORd, where Rd is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C6-C10 aryl, 4-6 membered heterocycloalkyl, or 5 to 6 memb
