KUNTZ, Kevin Wayne,CHESWORTH, Richard,DUNCAN, Kenneth William,KEILHACK, Heike,WARHOLIC, Natalie,KLAUS, Christine,SEKI, Masashi,SHIROTORI, Syuji,KAWANO, Satoshi,WIGLE, Timothy James Nelson,KNUTSON, Sar
申请号：
ES12719529
公开号：
ES2589555T3
申请日:
2012.04.13
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of Formulas (I) or a pharmaceutically acceptable salt thereof ** Formula ** wherein, X1 is N or CR11； X2 is N or CR13； Z is NR7R8, OR7, S (O) nR7, or CR7R8R14, where n is 0, 1 or 2； each of R1, R5, R9 and R10, independently, is H or C1-C6 alkyl optionally substituted with one or more substituents selected from the group consisting of halo, hydroxyl, COOH, C (O) O-C1-C6 alkyl, cyano, C1-C6 alkoxy, amino, mono-C1-C6-alkyl, di-C1-C6-alkyl, C3-C8 cycloalkyl, C6-C10 aryl, 4 to 12 membered heterocycloalkyl and 5 or 6 membered heteroaryl ； each of R2, R3 and R4, independently, is -Q1-T1, wherein Q1 is a C1-C3 alkyl linker or linker optionally substituted with halo, cyano, hydroxyl or C1-C6 alkoxy, and T1 is H, halo , hydroxy, COOH, cyano or RS1, wherein RS1 is C1-C3 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy, C (O) O-C1-C6 alkyl, C3-C8 cycloalkyl, C6-C10 aryl, amino, mono-C1-C6-alkyl, di-C1-C6-amino alkyl, 4-12 membered heterocycloalkyl or 5 or 6 membered heteroaryl, and RS1 is optionally substituted with one or more selected substituents from the group consisting of halo, hydroxyl, oxo, COOH, C (O) O-C1-C6 alkyl, cyano, C1-C6 alkoxy, amino, mono-C1-C6-alkyl, di20 C1-C6-alkyl alkyl, C3-C8 cycloalkyl, C6-C10 aryl, 4-12 membered heterocycloalkyl or 5 or 6 membered heteroaryl； R6 is C6-C10 aryl or 5- or 6-membered heteroaryl, each of which is optionally substituted with one or more -Q2-T2, wherein Q2 is a C1-C3 alkyl bond or linker optionally substituted with halo, cyano, hydroxy or C1-C6 alkoxy, and T2 is H, halo, cyano, -ORa, -NRaRb, - (NRaRbRc) + A ~, -C (O) Ra, -C (O) ORa, - C (O) NRaRb , -NRbC (O) Ra, -NRbC (O) ORa, -S (O) 2Ra, -S (O) 2NRaRb or RS2, in which each of Ra, Rb and Rc is independently H or RS3, A ~ is a pharmaceutically acceptable anion, each of RS2 and RS3, independently, is C1-C6 alkyl, C3-C8 cycloalkyl, C6-C10 aryl, 4-12 membered heterocycloalkyl or 5 or 6 membered heteroaryl, or Ra and Rb, together with the N atom to which they are attac
