California Pacific Medical Center;Catholic Healthcare West, d.b.a. St. Mary's Medical Center
发明人:
申请号：
EP04775891.7
公开号：
EP1617843B1
申请日:
2004.04.14
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
Certain N-deacetylcolchicine and N-deacetylthiocolchine derivatives are described wherein the 7-N position on the B ring is substituted with the group -C(O)-(CHR 4 ) m AR, wherein m is an integer of 0-10, A is S, O, N or a covalent bond； R 1 is substituted phenyl or substituted benzoyl； optionally substituted cycloalkyl of 3-7 carbons； optionally substituted naphtyl； an optionally substituted imide ring； an optionally substituted 5 or 6 member heterocycle with at least one N, S, or O in the ring； or an optionally substituted fused heterocyclic or fused carboxyclic ring system； R 2 (at the 2-position of the A ring) is methoxy, hydroxy, or methylenedioxy when taken together with R 3 ； R 3 (at the 3-position of the A ring) is methoxy, hydroxy, a monosaccharide radical, or is methylenedioxy when taken together with R 2 ； and R 4 is H or is H or methyl when m is 1. Also dimers of such compounds are disclosed. When combined with suitable pharmaceutical excipients, these compounds are useful for treating various types of cancer.
