Certain N-deacetylcolchicine and N-deacetylthiocolchine derivatives are described wherein the 7-N position on the B ring is substituted with the group - C(O)-(CHR4)m-AR, wherein m is an integer of 0-10, A is S, O, N or a covalent bond R1 is substituted phenyl or substituted benzoyl optionally substituted cycloalkyl of 3-7 carbons optionally substituted naphtyl an optionally substituted imide ring an optionally substituted 5 or 6 member heterocycle with at least one N, S, or O in the ring or an optionally substituted fused heterocyclic or fused carboxyclic ring system R2 (at the 2-position of the A ring) is methoxy, hydroxy, or methylenedioxy when taken together with R3 R3 (at the 3-position of the A ring) is methoxy, hydroxy, a monosaccharide radical, or is methylenedioxy when taken together with R2 and R4 is H or is H or methyl when m is 1. Also dimers of such compounds are disclosed. When combined with suitable pharmaceutical excipients, these compounds are useful for treating various types of cancer.
