The present invention relates to a compound according to formula (I)wherein R1is selected from the group consisting of 5- and 6- membered heteroaryl, (C1-C6)alkyl, (C3-C6)cycloalkyl, (4-6)-membered heterocycloalkyl and phenyl； R2is selected from (C1-C3)alkyl and halo(C1-C3)alkyl； R3is selected from phenyl, 5-membered heteroaryl and 6-membered heteroaryl； R4is selected from hydrogen, halogen, (C1-C4)alkyl and halo(C1-C4)alkyl； X1is selected from CH, C(Rb) and N, X2is selected from CH and N； Y is selected from -NH- and -O-； m is 0 or 1； n is 0 or 1； L represents a bond, -O-, -NH- or -N(Rc)-； or pharmaceutically acceptable salts, hydrates, or solvates thereof. The invention relates further to intermediates for the preparation of said compounds, to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases with said compounds, and to the use of said compounds in the manufacture of medicaments.本發明係關於根據式(I)之化合物其中R1係選自由5員及6員雜芳基、(C1至C6)烷基、(C3至C6)環烷基、(4至6)員雜環烷基及苯基組成之群；R2係選自(C1至C3)烷基及鹵基(C1至C3)烷基；R3係選自苯基、5員雜芳基及6員雜芳基；R4係選自氫、鹵素、(C1至C4)烷基及鹵基(C1至C4)烷基；X1係選自CH、C(Rb)及N，X2係選自CH及N；Y係選自-NH-及-O-；m為0或1；n為0或1；L表示一鍵、-O-、-NH-或-N(Rc)-；或其醫藥學上可接受之鹽、水合物或溶劑合物。本發明進一步係關於用於製備該等化合物之中間物、用於療法之該等化合物、包含該等化合物之醫藥組合物、使用該等化合物治療疾病之方法、及以該等化合物用於製備藥劑之用途。
