AICHER DANIEL,WIEHE ARNO,STARK CHRISTIAN B W,ALBRECHT VOLKER,GRAFE SUSANNA
申请号：
IN1429/CHENP/2013
公开号：
IN2013CN01429A
申请日:
2013.02.21
申请国别(地区):
IN
年份:
2015
代理人:
摘要：
ßThe present invention provides methods to obtain biologically active compounds that can be used as photosensitizers for diagnostic and therapeutic applications particularly for PDT of cancer infections and other hyperproliferative diseases fluorescence diagnosis and PDT treatment of a non tumorous indication such as arthritis inflammatory diseases viral or bacterial infections dermatological ophthalmological or urological disorders. An embodiment of the present invention consists of a method to synthesize diketo chlorins as precursors. In yet another embodiment these precursors are converted to unctionalized hydroxy and dihydroxy chlorins. Another embodiment is to provide amphiphilic compounds with a higher membrane affinity and increased PDT efficacy. Another embodiment consists of the formulation of the desired isomer into a liposomal formulation to be injected avoiding undesirable effects like precipitation at the injection site or delayed pharmacokinetics of the tetrapyrrole systems.
