Bluepharma - Industria Farmaceutica, S.A.;Universidade de Coimbra
发明人:
Da Silva Arnaut Moreira, Luis Guilherme,Miguens Pereira, Maria,Formosinho Sanches Simoes, Sebastiao Jose,Magalhaes Simoes, Sergio Paulo,Urbanska, Krystyna,Stochel, Grazynia
申请号：
AU2009307106
公开号：
AU2009307106B2
申请日:
2009.10.22
申请国别(地区):
AU
年份:
2015
代理人:
摘要：
The invention provides the methods of preparation, properties, pharmaceutical compositions and methods of therapy of sulfonated chlorins and bacterioclorins designed for the photodynamic therapy (PDT) of hyperproliferative tissues such as tumors, hyperproliferative blood vessels and other disorders or abnormalies that are responsive to PDT. In particular, the economical large-scale synthesis of stable chlorins and bacteriochlorins is described. Their properties were tailored to meet those of ideal photosensitizers for PDT. In another embodiment, pharmaceutical compositions and methods of therapy for systemic administration are provided. In a further embodiment, pharmaceutical compositions and methods of therapy for topical administration are also provided. Further provided is a method of labeling a target tissue and providing an image of that tissue by fluorescence of magnetic resonance imaging.
