WALTER HONG SHONG CHANG,张恒雄,張恒雄,LIN, CHENG AN,林政鞍,林政鞍,YANG, TING YA,杨婷雅,楊婷雅,LEE, CHIH HSIEN,李志贤,李志賢,RALPH ALEXANDER SPERLING,拉尔夫 亚历山大 士柏林,拉爾夫 亞歷山大 士柏林,WOLFGANG PARAK,沃尔夫冈 派瑞克,沃爾夫岡 派瑞克
申请号：
TW097133042
公开号：
TWI361081B
申请日:
2008.08.29
申请国别(地区):
TW
年份:
2012
代理人:
摘要：
The present invention discloses a fluorescent gold nanocluster, comprising: a dihydrolipoic acid ligand (DHLA) on the surface thereof, wherein the fluorescent gold nanocluster generates fluorescence by the interaction between the dihydrolipoic acid ligand and the nanocluster and the particle diameter of the fluorescent gold nanocluster is between 0.5 nm and 3 nm, wherein the wavelength of the emission fluorescence of the fluorescent gold nanocluster is between 400 nm and 1000 nm. In addition, the fluorescent gold nanocluster is used as bioprobes and/or applied in fluorescent biological label, clinical image as contrast medium, clinical detection, clinical trace, and clinical treatment etc.本發明揭露一種螢光金奈米團簇(Fluorescent gold nanocluster)及其形成方法。上述螢光金奈米團簇表面具有一種二氫硫辛酸配體,其中,上述螢光金奈米團簇係藉由上述二氫硫辛酸配體與上述奈米團簇間之作用而產生螢光性質,且上述螢光金奈米團簇之粒徑範圍為0.5nm至3nm,其中,上述螢光金奈米團簇之光激螢光波長範圍為400至1000nm,此外,上述之螢光金奈米團簇能作為生物探針(bioprobes),並具有下列之應用:如生物螢光標記、臨床醫療影像顯影劑以及臨床醫療檢測、追蹤與治療等。
