FIELD: medicine.SUBSTANCE: invention relates to medicine and can be used for preventing and treating venous thrombosis in the management of patients with a central venous catheter. Method includes the anticoagulant therapy in prophylactic mode immediately after catheter placement and performing ultrasound investigation of the corresponding vein area. Wherein the ultrasound investigation is performed three days after the catheter placement and the whole intravenous part of the catheter, vein walls in the puncture area and vein sections 3 cm above and below the catheter projection are examined. If thrombotic masses are detected in the vein lumen, the catheter is removed and anticoagulant therapy is continued at therapeutic doses.EFFECT: method allows effectively preventing and treating venous thrombosis, including by optimizing the number of performed ultrasound investigations with complete control of the status of the catheterized vessel within up to three days.1 cl, 1 ex