The present invention relates to effect of the plasminogen in terms of fresh and outmoded thrombus is dissolved.Compared with the medicine of existing other thrombus, plasminogen of the present invention can SL thrombus without causing the side effects such as bleeding.Medicine of the invention also has fresh and outmoded thrombus and the advantage with long half time and thrombus dissolving intensity controlled of can dissolve, therefore, plasminogen is likely to become the strategy of the brand-new internal thrombus of dissolving.