ХЕЙЗЕН Стэнли Л. (US),ЛЕВИСОН Брюс (US),ВАН Чжэньэн (US)
申请号：
RU2014153787
公开号：
RU2014153787A
申请日:
2013.06.11
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. A method of treating and / or preventing cardiovascular disease and / or thrombosis, comprising the following steps: a) identifying the subject as having increased platelet aggregation and / or elevated TMAO levels； and b) administering to said subject: i) a composition that contains a compound, selected from the group consisting of: N, N-dimethylethanolamine (DMEA), N-methylethanolamine (MEA), ethanolamine (EA), trimethylsilylethanol and P, P, P-trimethylethanolphosphine； and / or ii) a composition that contains a compound represented by formula I: wherein n is an integer or n is 0, indicating that CH is absent； where Y is C, Si, P, S, Ge, Sn, Pb, P , As, Sb or Bi； where X represents O or S, and the corresponding bond is present, absent, or double； where R represents H, an alkyl group, an alkenyl group, an alkynyl group, a phenyl group or a benzyl group； where Z represents C, CH, CH, O or S； where XR is an ester, thioester or thione ester； hl ycerin or one of the following three formulas: or where R ′ is H, an alkyl group, an alkenyl group, an alkynyl group, a phenyl group or a benzyl group； where X ′ represents O or S.2. The method of claim 1, further comprising administering to said subject a prebiotic, probiotic, and / or dietary fiber. A method according to claim 1, characterized in that said identification includes viewing the results of a platelet aggregation analysis carried out in a sample obtained from said subject, which exhibits increased platelet aggregation. The method according to claim 1, characterized in that the identification includes viewing the results of the analysis of TMA or TMAO conducted in the sample or1. Способ лечения и/или профилактики сердечно-сосудистого заболевания и/или тромбоза, включающий следующие этапы:a) идентификацию субъекта как имеющего повышенную агрегацию тромбоцитов и/или повышенные уровни ТМАО иb) введение указанному субъекту: i) композиции, которая содержит соединение, выбранное из группы, состоящей из: N,N-диметилэт
