The Trustees of the University of Pennsylvania;Novartis AG
发明人:
Avery D. Posey,Sonia Guedan Carrio
申请号：
US16481181
公开号：
US20190389928A1
申请日:
2018.01.26
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The invention provides compositions and methods for treating diseases associated with expression of a cancer associated antigen as described herein. The invention also relates to chimeric antigen receptor (CAR) specific to a cancer associated antigen as described herein, vectors encoding the same, and recombinant T cells comprising the CARs of the present invention. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises an antigen binding domain that binds to a cancer associated antigen as described herein. The CAR may comprise a mutant CD28 costimulatory domain.
