CRAIG W. LINDSLEY,P. JEFFREY CONN,MICHAEL R. WOOD,COREY R. HOPKINS,BRUCE J. MELANCON,MICHAEL S. POSLUSNEY,DARREN W. ENGERS
申请号:
PT12843949
公开号:
PT2770997T
申请日:
2012.10.28
申请国别(地区):
PT
年份:
2016
代理人:
摘要:
In one aspect, the invention relates to substituted 2-(4-heterocyclylbenzyl)isoindolin-1-one analogs compounds, derivatives thereof, and related compounds which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M 1 (mAChR M 1 ) synthesis methods for making the compounds pharmaceutical compositions comprising the compounds and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.