A sign holder system having a back plate and a front plate. The back plate is mountable to a wall surface, and the front plate is removably secured to the back plate. The front plate has a forward-facing surface for displaying indicia, such as a room number or a person's name. The back plate includes at least one recessed opening for receiving a clip attached to the back of the front plate. The recessed opening also includes a recessed pocket. The clip can be slid into the recessed pocket to secure the front plate to the back plate. The recessed pocket can have a ridge which engages with an elevated portion of the clip having similar or matching geometry. The ridge can have a wall that abuts the clip to lock the clip over the ridge. The back plate can additionally include a keyway for permitting a key to pass therethrough. The key has an end that, when inserted through the keyway, deflects the clip away from the ridge, thereby releasing the clip from the ridge and permitting the front plate to be released fro