A compound of formula (II): ** Formula ** or a tautomer thereof, N-oxide thereof, pharmaceutically acceptable ester thereof, or pharmaceutically acceptable salt thereof, wherein each occurrence of R1 is independently H, alkyl substituted or unsubstituted, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, or halogen； X is CH or N； each occurrence of R is independently H, substituted or unsubstituted alkyl, or halogen； Ra is substituted or unsubstituted alkyl； Rb is independently selected from H and substituted or unsubstituted alkyl； Rc is H, substituted or unsubstituted alkyl, -NH2 or halogen； each occurrence of n is independently selected from 0, 1, 2, 3, and 4； and Cy is selected from ** Formula ** where R2 and R3 are independently selected from H, halogen, hydroxyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, CN, -NH-SO2-R '-NO2, -NH2, -NH-C (O) -R ', -C (O) -NH-R', -SO2-R 'and -SO2NR'R'； R 'is selected from H, hydroxy, halogen, carboxyl, cyano, nitro, oxo (>； = O), thio (>； = S), substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted alkenyl, alkynyl substituted or unsubstituted, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted cycloalkylalkyl, substituted or unsubstituted cycloalkenylalkyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted, substituted or unsubstituted aryl, substituted or substituted arylalkyl unsubstituted, substituted or unsubstituted heteroaryl, and substituted or unsubstituted heteroarylalkyl； and R4 is H or substituted or unsubstituted alkyl.U compuesto de fórmula (II):**Fórmula** o un tautómero del mismo, N-óxido del mismo, éster farmacéuticamente aceptable del mismo, o sal farmacéuticamente aceptable del mismo, en la que cada aparición de R1 es independientemente H, alquilo sustituido o sin sustituir, alquenilo sustituido o sin sustituir, alquinilo
