3,4-Dihydropyrazine [2,3-b] pyrazin-2 (1H) -one compounds as mTOR kinase inhibitors for oncological indications and diseases associated with the mTOR / PI3K / Akt pathway
A compound having the formula (II): ** Formula ** or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof, wherein: R1 is pyridyl substituted with one or more substituents independently selected from the group consisting of C1- alkyl 8 substituted or unsubstituted, substituted or unsubstituted heterocyclyl, halogen, aminocarbonyl, cyano, hydroxyalkyl, -OR and -NR2, where each R is independently H, or a substituted or unsubstituted C1-4 alkyl； R2 is substituted or unsubstituted cycloalkyl, and R3 is H, or a substituted or unsubstituted C1-8 alkyl； wherein the term "substituted" denotes a substitution with any of the substituents recited in the subsequent claims or with halogen； I rent； hydroxyl； alkoxy； alkoxyalkyl； Not me； alkylamino； carboxy； nitro； cyano； thiol； thioether； imine； imide； amidine； guanidine； enamine； aminocarbonyl； acylamino； phosphonate； phosphine； thiocarbonyl； sulfonyl； sulfone； sulfonamide； ketone； aldehyde； ester； urea； urethane； oxime； hydroxyl amine； alkoxyamine； aralkoxyamine； N-oxide； hydrazine； hydrazide； hydrazone； azide； isocyanate； isothiocyanate； cyanate； thiocyanate； oxygen (>； = O)； B (OH) 2, O (alkyl) aminocarbonyl； cocloalkyl, which may be monocyclic or polycyclic condensed or non-condensed； heterocyclyl； which can be monocyclic or polycyclic condensed or non-condensed； condensed or non-condensed monocyclic or polycyclic aryl or heteroaryl； aryloxy； aralkyloxy； heterocyclyloxy or heterocyclyl alkoxy.Un compuesto que presenta la fórmula (II): **Fórmula** o una sal, estereoisómero o tautómero farmacéuticamente aceptable del mismo, donde: R1 es piridilo sustituido con uno o más sustituyentes seleccionados de forma independiente del grupo que consiste en alquilo C1-8 sustituido o sin sustituir, heterociclilo sustituido o sin sustituir, halógeno, aminocarbonilo, ciano, hidroxialquilo, -OR y -NR2, donde cada R es de forma independiente H, o un alquilo C1-4 sustituido o sin sustituir； R2 es cicloalquilo sustituido o sin
