Processes for preparing {1 - {[1 - 3 - fluoro - 2 - (trifluoromethyl) isonicotinoil piperidin-4-yl il}] - 3 - [4 - (7H pyrrolo [2,3-d] pyrimidin-4-yl) - 1H pyrazol-1-yl] - 3 - azetidin il} acetonitrile jak inhibitors and Compounds； intermediaries, intermediary and Compound (3 - (trifluoromethyl) fluoro 2 - (pyridin-4-yl) dioxa - 1.4 - 8 - Zaspiro [4,5] decan - 8 - il) methanone.

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专利权人:

INCYTE HOLDINGS CORPORATION

发明人:

ZHOU, JIACHENG,LIU, PINGLI,WU, YONGZHONG,CAO, GANFENG

申请号：

CL2014000534

公开号：

CL2014000534A1

申请日:

2014.03.05

申请国别(地区):

CL

年份:

2014

代理人:

摘要：

This invention relates to processes and intermediates for making {1-{1-[3-fluoro-2-(trifluoromethyl)isonicotinoyl]piperidin-4-yl}-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile, useful in the treatment of diseases related to the activity of Janus kinases (JAK) including inflammatory disorders, autoimmune disorders, cancer, and other diseases.PROCESOS PARA PREPARAR {1-{1-[3-FLUORO-2-(TRIFLUOROMETIL)ISONICOTINOIL]PIPERIDIN-4-IL}-3-[4-(7H-PIRROLO[2,3-D]PIRIMIDIN-4-IL)-1H-PIRAZOL-1-IL]AZETIDIN-3-IL}ACETONITRILO Y COMPUESTOS INTERMEDIARIOS, INHIBIDORES DE JAK； Y COMPUESTO INTERMEDIARIO (3-FLUORO-2-(TRIFLUOROMETIL)PIRIDIN-4-IL)(1,4-DIOXA-8-AZASPIRO[4,5]DECAN-8-IL)METANONA.

来源网站：

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http://www.ckcest.cn/home/