N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors

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专利权人:

INCYTE CORPORATION

发明人:

ZHU WENYU,WANG HAISHENG,STORACE LOUIS,SHAO LIXIN,FOLMER BEVERLY,GLENN JOSEPH P,ARVANITIS ARGYRIOS G,RODGERS JAMES D,SHEPARD STACEY

申请号：

NZ59647910

公开号：

NZ596479A

申请日:

2010.05.21

申请国别(地区):

NZ

年份:

2014

代理人:

摘要：

Disclosed is a compound of formula I, such as 3-[1-(6-chloropyrazin-2-yl)pyrrolidin-3-yl]-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile and 3-[1-(6-chloropyridin-2-yl)pyrrolidin-3-yl]-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile, which is useful for modulating JAK1 and treating autoimmune, cancer and inflammatory diseases.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/