PYRROLOBENZODIAZÉPINES ET CONJUGUÉS ASSOCIÉS

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专利权人:

SPIROGEN SÀRL;GENENTECH, INC.

发明人:

申请号：

EP12780356.7

公开号：

EP2750713B1

申请日:

2012.10.12

申请国别(地区):

EP

年份:

2015

代理人:

摘要：

A conjugate of formula (A): where Y is selected from a single bond, and a group of formulae A1 or A2: where N shows where the group binds to the N10 of the PBD moiety； RL1 and RL2 are independently selected from H and methyl, or together with the carbon atom to which they are bound form a cyclopropylene group； CBA represents a cell binding agent； Q is independently selected from O, S and NH； R11 is either H, or R or, where Q is O, SO3M, where M is a metal cation.

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