VISWAJANANI J. SATTIGERI,VENKATA P. PALLE,SUNANDA G. DASTIDAR,MANOJ KUMAR KHERA,RANADHEER REDDY,MANOJ KUMAR TIWARI,AJAY SONI,ABDUL REHMAN,SONY JOSEPH,ARPITA MUSIB,PUNIT KUMAR SRIVASTAVA
申请号：
BRPI0715231
公开号：
BRPI0715231A2
申请日:
2007.08.21
申请国别(地区):
BR
年份:
2013
代理人:
摘要：
COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND THEIR USES, CHIRAL AID AND ITS USE AND PROCESSES TO PREPARE A COMPOUND. The present invention relates to substituted amino-hydroxy and carboxylic acids which act as matrix metalloprotease inhibitors, particularly diastereoisomerically pure carboxylic acid, corresponding processes for their synthesis and pharmaceutical compositions containing the same. compounds of the present invention. Compounds of the present invention are useful in the preparation of medicaments for the treatment of various inflammatory, autoimmune and allergic diseases, such as methods of treating asthma, rheumatoid arthritis, chronic obstructive pulmonary disease (COPD), rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis, healing disorders, pulmonary inflammation, acute respiratory distress syndrome, periodontitis, multiple sclerosis, gingivitis, atherosclerosis, neointimal hyperplasia leading to restenosis and ischemic cardiac arrest, stroke, kidney disease, tumor metastasis, and other inflammatory disorders characterized by overexpression and overactivating a matrix metalloproteinase using the compounds.COMPOSTOS, COMPOSIÇÕES FARMACÊUTICAS E SEUS USOS, AUXILIAR QUIRAL E SEU USO E PROCESSOS PARA PREPARAR UM COMPOSTO. A invenção presente se refere a ácidos carboxílicos<；225>；-hidróxi e a amino substituidos, os quais agem como inibidores de metaloprotease de matriz, particularmente <；225>；-hidróxi ácidos carboxílicos diastereoisomericamente puros, processos correspondentes para a sua síntese e composições farmacêuticas contendo os compostos da presente invenção. Compostos da presente invenção são úteis no preparo de medicamentos para o tratamento de várias doençasinflamatórias, autoimunes e alérgicas, como métodos de tratar asma, artrite reumatoide, doença pulmonar obstrutiva crônica (COPD), rinite, osteoartrite, artrite psoriática, psoríase, fibrose pulmonar, distúrbios de cicatrização, inflamação pulmonar, síndrome da
