KALOFONOS, ISABEL,STAHLY, G. PATRICK,MARTIN-DOYLE, WILLIAM,KALOFONOS, DIMITRIS,STULTS, JEFFREY S.,HOUSTON, TRAVIS L.
申请号：
CA2738231
公开号：
CA2738231C
申请日:
2009.09.03
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The invention relates to a novel choline cocrystal of 5-[(1Z.2E)-2-methyl-3-phenylpropenylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid. The preparation and characterization of thenovel choline cocrystal according to variousembodiments of the invention is described. The invention also relates topharmaceutical compositions containing the novel cholinecocrystal and the therapeutic use of the novel choline cocrystal to treatand/or prevent various conditions, including treating and/orpreventing diabetic complications, treating and/or preventing homocystinuriareducing levels of homocysteine in blood serum,inhibiting aldose reductase, and affording cardioprotection in non-diabeticpatients.
