Vyzkumny Ustav Veterinarniho lékarstvi, v.v.i.;Ustav organicke chemie a biochemie AV CR, v.v.i.
发明人:
申请号：
EP13704708.0
公开号：
EP2802556B1
申请日:
2013.01.14
申请国别(地区):
EP
年份:
2017
代理人:
摘要：
The invention provides new lipopolyamines of spermine type of the general formula I, wherein X is C&mdash；N bond or aminopolyethyleneglycolcarboxamide linker or o-hydroxy-alkylcarboxamide linker or &omega；-hydroxyalkylcarboxamidopolyethyleneglycol-carboxamide linker, and wherein a hydrophobic domain Y is an acyl symmetrically branched in the position C(2) or cholesteryl. The invention further provides a method of preparation of said lipopolyamines and their use for construction of polycationic liposomal drug carriers.
