Lipopolyamines of spermine type for construction of liposomal transfection systems

• 收藏
• 分享

专利权人:

USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I.;VYZKUMNY USTAV VETERINARNIHO LEKARSTVI, V.V.I.

发明人:

Lukas Drasar,Miroslav Ledvina,Zina Korvasova,Jaroslav Turanek

申请号：

US14370526

公开号：

US09393200B2

申请日:

2013.01.14

申请国别(地区):

US

年份:

2016

代理人:

摘要：

The invention provides new lipopolyamines of spermine type of the general formula I, wherein X is C—N bond or aminopolyethyleneglycolcarboxamide linker or o-hydroxy-alkylcarboxamide linker or ω-hydroxyalkylcarboxamidopolyethyleneglycol-carboxamide linker, and wherein a hydrophobic domain Y is an acyl symmetrically branched in the position C(2) or cholesteryl. The invention further provides a method of preparation of said lipopolyamines and their use for construction of polycationic liposomal drug carriers.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/