BENZENESULFONAMIDE UPREGULATORS OF NPC1 FOR NEIMANN-PICK DISEASE AND OTHER LYSOSOMAL STORAGE DISORDERS

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专利权人:

Icahn School of Medicine at Mount Sinai

发明人:

PATNAIK, Samarjit,TAYLOR, Mercedes,CALVO, Raul Rolando,MARUGAN, Juan Jose,SOUTHALL, Noel,ZHENG, Wei,FERRER-ALEGRE, Marc,DEHDASTHI, Seameen,DRANCHAK, Patricia,CHEN, Fannie,IOANNOU, Yiannis

申请号：

EP16749864

公开号：

EP3256116A4

申请日:

2016.02.11

申请国别(地区):

EP

年份:

2018

代理人:

摘要：

Methods and compositions for treating lysosomal storage disorders are disclosed. The methods involve administering a genus of benzenesulfonamides, particularly N-[3-(aminosulfonyl)phenyl]-benzamides and heteroarylamides. A genus of suitable compounds is shown in formula I:

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