BENZENESULFONAMIDE UPREGULATORS OF NPC1 FOR NEIMANN-PICK DISEASE AND OTHER LYSOSOMAL STORAGE DISORDERS

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专利权人:

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

发明人:

PATNAIK, SAMARJIT,TAYLOR, MERCEDES,CALVO, RAUL ROLANDO,MARUGAN, JUAN JOSE,SOUTHALL, NOEL,ZHENG, WEI,FERRER-ALEGRE, MARC,DEHDASTHI, SEAMEEN,DRANCHAK, PATRICIA,CHEN, FANNIE,IOANNOU, YIANNIS

申请号：

CA2976449

公开号：

CA2976449A1

申请日:

2016.02.11

申请国别(地区):

CA

年份:

2016

代理人:

摘要：

Methods and compositions for treating lysosomal storage disorders are disclosed. The methods involve administering a genus of benzenesulfonamides, particularly N-[3-(aminosulfonyl)phenyl]-benzamides and heteroarylamides. A genus of suitable compounds is shown in formula I:

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